It is without a doubt one of Jimmy Kimmel Live's most beloved segments.

And Halle Berry did not disappoint when she delivered a hilarious response to a mean tweet that declared her 'boobs are lopsided' during the show's Mean Tweets skirt on Thursday.

To the delight of the audience, the 49-year-old replied with a laugh: 'Well, when they're real, that happens.'

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Candid: Halle Berry delivered a hilarious response to a tweeter who critiqued her cleavage on Thursday during Jimmy Kimmel Live's Mean Tweets segment

Halle was certainly dressed to impress when she stepped out onto the stage.

The first celebrity to face the wrath of tweeters that day, Halle looked fantastic in a sheer black turtleneck that exposed her cleavage and black bra. 

The see-through top also showcased her flat belly to full effect, while tight black trousers hugged her fantastic legs. 

Starting a buzz: Berry looked fantastic in a black bra and sheer turtleneck when she stepped out on stage

'No me though': Tobey Maguire said the tweet wasn't referring to him because 'its spelled differently' 

Other celebrities to take part included Naomi Watts, George Clooney, and Tobey Maguire.

'Conspiracy theory: Toby Maguire is just a hamster in a robot,' Tobey read @VMB_73's tweet from the phone, before adding, 'Not me though, 'cause it's spelled differently.' 

Naomi then stepped out clutching her phone, where she read @beddlet's tweet: 'Not to be mean but Naomi Watts has such a blah face? I look at it and it's just nothing, like a blank space where features should be.' 

'Not to sound mean': Naomi Watts read a tweet from @beddlet while sporting a sheer black-and-white top

Uncertain: The actress appeared uncertain of how to respond after reading off the comment

Last was George, who stepped out to a roaring audience in a crisp grey blazer. 

'Hey George Clooney, your hair cut sucks. Oh and so does your sense of humour. I'm on you all night, f**k boy,' the actor read @LowKeyUHTN's tweet, before heading off stage. 

The skit no doubt was a nice change of pace for Halle.

Aside from the second season finale of her CBS series Extant, which aired earlier in September, Halle will next appear on the big screen in action thriller Kidnap.

The Luis Prieto-directed flick - which follows a mother who will stop at nothing to recover her kidnapped son - is due in theaters this February. 

'So does your sense of humour': George Clooney recited @LowKeyUHTN's tweet for the audience

Not amused? The actor walked off stage after reading the tweet

On the way: Shonda Rhimes made her way to the studios

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